Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin
نویسندگان
چکیده
منابع مشابه
Host-gut microbiota metabolic interactions.
The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the ...
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UNLABELLED The gut microbiota enhances the host's metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems. We have probed the systemic metabolic adaptation to gut colonization for 20 days following exposure of axenic mice (n = 35) to a typical environmental microbial background using high-resolution (1)H nuclear magnet...
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Brandl K, Kumar V, Eckmann L. Gut-liver axis at the frontier of hostmicrobial interactions. Am J Physiol Gastrointest Liver Physiol 312: G413–G419, 2017. First published February 23, 2017; doi:10.1152/ajpgi.00361.2016.—Liver and intestine are tightly linked through the venous system of the portal circulation. Consequently, the liver is the primary recipient of gut-derived products, most promine...
متن کاملMetabolic surgery profoundly influences gut microbial-host metabolic cross-talk.
BACKGROUND AND AIMS Bariatric surgery is increasingly performed worldwide to treat morbid obesity and is also known as metabolic surgery to reflect its beneficial metabolic effects especially with respect to improvement in type 2 diabetes. Understanding surgical weight loss mechanisms and metabolic modulation is required to enhance patient benefits and operative outcomes. METHODS The authors ...
متن کاملGut-liver axis at the frontier of host-microbial interactions.
Liver and intestine are tightly linked through the venous system of the portal circulation. Consequently, the liver is the primary recipient of gut-derived products, most prominently dietary nutrients and microbial components. It functions as a secondary "firewall" and protects the body from intestinal pathogens and other microbial products that have crossed the primary barrier of the intestina...
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ژورنال
عنوان ژورنال: Translational Research
سال: 2017
ISSN: 1931-5244
DOI: 10.1016/j.trsl.2017.08.005